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Tirzepatide in the clinical record Tirzepatide's evidence base sits in the SURMOUNT program — SURMOUNT (tirzepatide for weight management, published in The New England Journal of Medicine , 2022) and SURMOUNT-OSA (tirzepatide for obstructive sleep apnea, NEJM 2024) — while the broader class includes GLP-1 receptor agonists such as semaglutide, liraglutide, and dulaglutide, studied in programs like STEP (semaglutide for weight management, NEJM 2021)
